Endocrine Abstracts

Thyroid storm (TS) is a rare but life-threatening manifestation of thyrotoxicosis.Objective: To describe the clinical features and outcomes of patients admitted for TS according to Burch-Wartofsky’s score (BW).Methods: A retrospective review of subjects admitted to a single hospital from 2009 through 2015 was conducted.Results: 15 cases were identified. Etiology: autoimmune (n=8), factitious (<e...

Introduction: Primary endocrine failure in β-Thal is caused by iron overload in epithelial cells and in interstitial macrophages. Autoimmune phenomena are not believed to play any significant role, although iron overload, through non-specific inflammatory process, could trigger autoimmunity, as recently suggested for the pathogenesis of diabetes mellitus in β-Thal patients.Purpose: We investigated thyroid function and anti-thyroid autoantibodie...

Introduction: There is no known reliability about an undetectable recombinant human TSH (rhTSH) stimulated serum thyroglobulin (Tg) concentrations, predicts no long-term relapse, or the threshold of it. An rhTSH-stimulated serum Tg determination was made to all patients with DTC that maintained undetectable baseline Tg and negative imaging tests. We correlate their findings with their long-term evolution.Methods: We collected 91 patients with DTC, 73 wom...

Introduction: Adrenal crisis due to primary adrenal insufficiency may result in severe morbidity and mortality if undiagnosed or ineffectively treated. Main manifestations are hypotension (>90%), hyponatremia (70–80%), and hyperkalemia (30–40%), while hypoglycemia is rare. An unusual case of a septic patient with hypokalemia and hypomagnesemia with hypoglycemic coma as first manifestation of acute adrenal insufficiency is presented.Case pre...

Background and Objective: Congenital adrenal hyperplasia (CAH) is one of the most common diseases in pediatric endocrinology. Non-classical (NC-CAH) forms are characterized by milder enzyme dysfunction and manifests commonly in adolescence or adulthood. The most frequent form of NC-CAH occurs due to 21-hydroxylase deficiency which is caused by defects in the CYP21A2 gene. Our aim was to describe the most common 21-hydroxylase gene (CYP21A2) mutations in our geographical area i...

Background: Cross-sex hormone treatments are used to masculinize or feminize the bodies of female-to-male (FtM) or male-to-female (MtF) transsexuals, respectively. Redistribution of fat mass is expected to occur during the first 1–6 months in transgender males and in the first 3–12 months in transgender females.Objective: To examine the effects of cross-gender sex hormone therapy (CHT) on body composition in transsexual men and women.<p cla...

Background: Male-to-female transsexual persons use estrogens + antiandrogens to adapt their physical bodies to the female sex.Estrogens are powerful stimulators of synthesis and release of prolactin and serum prolactin levels are usually somewhat increased following estrogen treatment.Objective: To determine prolactin levels and to assess the risk of development of prolactinoma in male-to-female transgender subjects following cross-sex hormone therapy (C...

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals1. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma ce...

Introduction: Thalassaemia syndromes are a group of inherited haemolytic disorders determining chronic anaemia, iron overload and organ damage (through the production of ROS), necessitating of iron chelation therapy. Nowadays, there is scant knowledge on hypercalciuria in thalassaemic Western patients. Therefore, aim of our study was evaluating the prevalence of hypercalciuria and identifying risk factors and clinical consequences associated with its development.<p class="...

Introduction: The parathyroid gland is made up of principal cells and oxyphilic cells, surrounded by stroma, whose main component is adipose tissue, which accounts for 25% of the content of the parathyroid in adults. In parathyroid adenomas, prominent parathyroid cellularity can be observed, with a very marked decrease in the stroma. Parathyroid lipoadenoma is a rare variant of parathyroid adenoma, characterized by hyperfunctioning parathyroid cells in an abundant fatty stroma...